Amgen Workers Helped U.S. in Aranesp Marketing Inquiry

“I hope no one is taping this,” the Amgen manager remarked at a company sales meeting in 2005.

The manager then boasted of how she had given a $10,000 unrestricted grant to a pet project of a doctor who was an adviser to the local Medicare contractor. In turn, she said, the doctor would help persuade the contractor to provide reimbursement for an unapproved use of Amgen’s anemia drug, Aranesp.

Someone, it turned out, was taping it. Jill Osiecki, a longtime sales representative at Amgen, was wearing a recording device under her clothes, transmitting the proceedings to agents of the Department of Health and Human Services.

The result of Ms. Osiecki’s undercover work, and information provided by other whistle-blowers, led to Amgen’s agreement this week to pay $762 million to settle federal investigations regarding the marketing of some of its top-selling drugs.

Judge Sterling Johnson Jr. of Federal District Court in Brooklyn accepted the settlement on Wednesday, clearing the way for 10 whistle-blower lawsuits to be unsealed.

Amgen, the world’s largest biotechnology company, will pay $150 million in criminal penalties after pleading guilty to one misdemeanor count of marketing Aranesp for unapproved uses and in unapproved doses.

The rest of the money — $612 million — will go to settle civil false claims lawsuits filed by the federal government, states and whistle-blowers. These contain accusations that go well beyond the off-label marketing of Aranesp.

They include off-label marketing of other drugs like Enbrel for psoriasis and Neulasta, which increases the levels of white blood cells. Amgen is also accused of offering kickbacks to doctors and clinics to induce them to use its drugs. These reportedly came as cash, rebates, free samples, educational and research grants, dinners and travel, and other inducements. The government also accused the company of knowingly misreporting the prices of some of its drugs.

Except for those in the criminal count, Amgen denied the other accusations, though it did issue a statement on Wednesday acknowledging the settlement.

“The government raised important concerns in the criminal prosecution,” Cynthia M. Patton, chief compliance officer at Amgen, said in the statement. “Amgen acknowledges that mistakes were made, and we did not live up to our standards.”

Ms. Osiecki, 52, was one of the main whistle-blowers and will be entitled to a share of the settlement. The amount each whistle-blower will receive has not been determined or is being kept confidential, their lawyers said.

Ms. Osiecki worked as a sales representative for Merck for nine years before joining Amgen in 1990, soon after the biotechnology company won regulatory approval for its first product. The company, based outside Los Angeles, had “good science, good products, strong ethics,” Ms. Osiecki said in an interview.

But, she said, the corporate culture changed starting around 2000. That was when new management came in and Aranesp was approved, setting up a fierce marketing battle with Johnson & Johnson and its rival anemia drug, Procrit.

“It was more important to make your numbers than to follow the rules,” said Ms. Osiecki, who was based in Milwaukee and sold Aranesp.

In August 2004, with her concerns mounting, Ms. Osiecki called the Office of Inspector General of the Department of Health and Human Services and left a message. Within days, she was called back, and she went to see an agent, who persuaded her to secretly record meetings. She did that 13 times over about 15 months, mainly sales meetings.

Aranesp is used mainly in a hospital, clinic or physician’s office. It is bought by the medical practice, which can make a profit if the patient and insurers pay more for the use of the drug than the practice paid.

Ms. Osiecki said Amgen “marketed the spread,” trying to make it more profitable for doctors to use Aranesp rather than Procrit.

Such financial inducements could also spur greater overall use of a drug and can violate anti-kickback laws, said Ms. Osiecki’s lawyer, Brian P. Kenney of Kenney & McCafferty in Blue Bell, Pa.

Ms. Osiecki said the first sales meeting at which she wore the recording device, wrapped around her midriff under baggy clothes, was in October 2004 in a Milwaukee hotel. She could look down from the meeting room and see the car parked across the street containing the agent with the receiving device. She said she was not particularly nervous.

The speaker was a pharmacist from an oncology practice going through the numbers on how his practice could make a million dollars more a year using Aranesp rather than Procrit.

Ms. Osiecki said Amgen was careful to cover up such marketing. Spreadsheets showing doctors how much more money they could make using Aranesp were “homemade bread,” meaning they were created by each sales representative, not by the company. And representatives were told not to leave the presentations behind after showing them to doctors.

Her 107-page complaint, filed in late 2004, contains many other accusations.

Other whistle-blowers made other accusations. Kassie Westmoreland, a former sales representative, said Amgen overfilled vials of Aranesp, essentially providing free drugs to doctors. They could then bill Medicare or private insurers for the use of that drug, making an extra profit.

“Amgen was offering a kickback in the form of extra product subsidized by the taxpayers,” said Robert M. Thomas Jr., one of Ms. Westmoreland’s lawyers.

Elena Ferrante and Marc Engelman, both former sales representatives, contended that Amgen promoted Enbrel’s off-label use for mild psoriasis when the drug was approved only for moderate or severe cases of the disease.

Lydia Cotz, one of their lawyers, said the two refused to go along with the off-label marketing. They are now pursuing wrongful termination claims against Amgen in arbitration proceedings that Amgen requires be kept confidential, she said.

“It’s been a very long heroic journey for my clients,” she said.

Ms. Osiecki is now also a former Amgen sales representative. She said that she was fired in December 2005 after she let slip that she had retained a company voice mail message that she thought provided evidence of illegal activity. Leaving the pharmaceutical industry, she moved to Amelia Island, Fla. She now works for a small business.

Mosi Secret and Barry Meier contributed reporting.

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Boehner: Blame tax hikes on Obama

US Speaker of the House John Boehner speaks on the "fiscal cliff" during press conference Wednesday. (Reuters / December 19, 2012)

Reuters

1:37 p.m. CST, December 19, 2012

President Barack Obama will be responsible for taxes rising on Americans if he does not "get serious" about a balanced deficit reduction plan or demand Senate passage of a Republican bill to prevent tax increases on all income below $1 million, House Speaker John Boehner charged on Wednesday.

"Tomorrow the House will pass legislation to make permanent tax relief for nearly every American," Boehner said in a short on-camera statement.

"Then the president will have a decision to make. He can call on the Senate Democrats to pass that bill, or he can be responsible for the largest tax increase in American history."

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Chicago prison inmates used bedsheets to escape: official

The scene at the Metropolitan Correctional Center and in Tinley Park, where authorities were searching for two escaped prisoners on Dec. 18, 2012. (Zbigniew Bzdak & Jose M. Osorio/Chicago Tribune)

Officials at a federal Loop jail discovered that two convicted bank robbers had escaped after employees arriving for work at about 7 a.m. today and saw a makeshift rope hanging from the outside of the high-rise facility, federal officials said in charging the two with escape.

Joseph "Jose" Banks and Kenneth Conley made good their escape from the Metropolitan Correctional Center after last being seen for a head count conducted at about 10 p.m. Monday, authorities said.

The two are believed to have scurried down ropes made from bedsheets from the high-rise cell they shared.

Authorities also revealed that in their cell guards found numerous articles of clothing and sheets piled under a blanket in both their beds to make it appear they were asleep.

The window in the cell was broken and the makeshift rope was tied to its bars and hanging down the south side of the MCC, authorities said.

Prosecutors charged both with escape in a criminal complaint filed this afternoon in federal court a few blocks from the scene of the escape.

Authorities said the two are believed to be traveling together and were reportedly last seen this morning in the Tinley Park area.

A widespread manhunt is underway by the FBI with the assistance of numerous federal, state and locallawenforcement agencies.

Both Banks and Conley were awaiting sentencing for bank robbery convictions. If they are captured and convicted of escape, they would face up to an additional five years in prison.

“A rope was fashioned out of bedsheets,’’ said a spokesman for the MCC. “I would imagine that they saved them up."

Conley and Banks, known as the Second-Hand Bandit who was convicted just last week, were first unaccounted for during a 5 a.m. head count, but it's unclear they were still inside the 27-story Metropolitan Correctional Center at the time, U.S. Marshal's Service spokeswoman Belkis Cantor said.

The makeshift rope could be seen dangling along the south side of the MCC, 71 W. Van Buren St.

The MCC spokesman declined to say whether any guards were under investigation or whether anything was smuggled into them or how the narrow cell window was widened.

Hours after the escape, SWAT teams forced their way into a Tinley Park house where a relative of Conley is believed to live. But no one was found inside, and FBI officials said they believe Conley and Banks had been there hours earlier.

The SWAT officers left the home after about 20 minutes and walked down the street with dogs as neighbors followed, taking pictures with their phones. About two blocks down, the officers searched the Metra stop.

A woman who answered at the home of a relative of Conley said it was "very upsetting for everyone" and declined further comment.

Banks’ cousin, Theresa Ann Banks, pleaded for Banks to turn himself in.

“I just don’t want to see him get hurt or killed,” she said with a shaky voice. “(The family) is trying to hold themselves together. We just have to have faith in God and hope everything goes right.”

Theresa Ann Banks said she received a call about the escape from Banks' father, who heard about it on the news.

When Joseph Banks was arrested in 2008, Theresa Ann Banks said she visited him whenever she had a chance. “When I went to see him, he was calm, he was humble, he was happy to see me,” she said. “He was very positive every time I would go.”

Banks was described as black, 37, 5 feet 8 inches tall and weighing 160 pounds. Conley is white, 38, 6 feet and 185 pounds.

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Newsman’s disappearance largely kept secret

NEW YORK (AP) — NBC was able to keep the abduction of chief Middle East correspondent Richard Engel in Syria largely a secret until he escaped late Monday because it persuaded some of this country’s most prominent news organizations to hold back on the story.

Otherwise, the disappearance of Engel — probably the most high-profile international television reporter on a U.S. network — would have been big news.

Engel and three colleagues, producers Ghazi Balkiz and Aziz Akyavas and photographer John Kooistra, escaped during a firefight between rebels and their captors, forces sympathetic to the Syrian government. The journalists were dragged from their cars, kept bound and blindfolded and threatened with death.

NBC said it did not know what had happened to the men until after their escape. The first sign of trouble came last Thursday, when Engel did not check back with his office at an agreed-upon time.

The Associated Press learned of Engel’s disappearance independently and was asked to keep the news quiet upon contacting NBC, said John Daniszewski, the AP’s vice president and senior managing editor.

“A general principle of our reporting is that we don’t want to write stories that are going to endanger the lives of the people that we are writing about,” Daniszewski said. The first few days after an abduction are often crucial to securing the captive’s release.

CBS News also said that it had honored NBC’s request, but a spokeswoman declined to discuss it. ABC, Fox News and CNN were also contacted by NBC.

CNN, in an editor’s note affixed to a website story on Engel’s escape, noted NBC’s request. CNN said it complied to allow fact-finding and negotiations to free the captors before it became a worldwide story.

“Hostage negotiators say that once the global spotlight is on the missing, the hostages’ value soars, making it much harder to negotiate their freedom,” CNN said.

For similar reasons, the AP did not report its own news several years ago when a photographer was kidnapped in the Gaza Strip, securing his release within a day. In one celebrated case of secrecy, The New York Times withheld news that reporter David Rohde was kidnapped while trying to make contact with a Taliban commander in Afghanistan. Rohde escaped after seven months in captivity.

It wasn’t clear whether Engel’s abductors knew what they had at the time. That knowledge, CNN argued, could have greatly complicated any negotiations. In this case, the captors did not make any ransom demands during the time he was missing.

This isn’t simply a professional courtesy; the AP has withheld news involving overseas contractors in the past, Daniszewski said. For similar reasons, the organization does not reveal details of military or police actions it learns about beforehand if the news will put people at risk, and doesn’t write about leaders heading into war zones until they are safely there.

Still, it’s not a decision lightly taken by news organizations. “The obligation of journalists is to report information, not withhold it, except in exceptional circumstances,” said Robert Steele, a journalism ethics professor at DePauw University.

The news that Engel was missing was first reported Monday by Turkish journalists who had heard about Akyavas’ involvement, and was picked up by the U.S. website Gawker.com. In explaining why the news was reported, Gawker’s John Cook wrote that no one had told him of a specific or even general threat to Engel’s safety.

“I would not have written a post if someone had told me that there was a reasonable or even remote suspicion that anything specific would happen if I wrote the post,” Cook wrote.

He also noted that China’s Xinhua News Agency and the Breitbart website had also reported on Engel’s disappearance. Breitbart’s John Nolte attached a note to his report saying that he wasn’t even aware of any news embargo until after hearing that Engel had been released.

The news was also tweeted by a small number of journalists, apparently unaware of the embargo request.

Whether a disappearance has become widely known could influence a decision by AP on whether to withhold the news, Daniszewski said. In this case, it wasn’t clear that it had been widely circulated, he said.

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Attackers in Pakistan Kill Anti-Polio Workers

Rizwan Tabassum/Agence France-Presse — Getty Images

A Pakistani mother mourned her daughter, who was killed on Tuesday in an attack on health workers participating in a drive to eradicate polio from Pakistan.

ISLAMABAD, Pakistan — Gunmen shot dead five female health workers who were immunizing children against polio on Tuesday, causing the Pakistani government to suspend vaccinations in two cities and dealing a fresh setback to an eradication campaign dogged by Taliban resistance in a country that is one of the disease’s last global strongholds.

“It is a blow, no doubt,” said Shahnaz Wazir Ali, an adviser on polio to Prime Minister Raja Pervez Ashraf. “Never before have female health workers been targeted like this in Pakistan. Clearly there will have to be more and better arrangements for security.”

No group claimed responsibility for the attacks, but most suspicion focused on the Pakistani Taliban, which has previously blocked polio vaccinators and complained that the United States is using the program as a cover for espionage.

The killings were a serious reversal for the multibillion-dollar global polio immunization effort, which over the past quarter century has reduced the number of endemic countries from 120 to just three: Pakistan, Afghanistan and Nigeria.

Nonetheless, United Nations officials insisted that the drive would be revived after a period for investigation and regrouping, as it had been after previous attacks on vaccinators here, in Afghanistan and elsewhere.

Pakistan has made solid gains against polio, with 56 new recorded cases of the diseases in 2012, compared with 192 at the same point last year, according to the government. Worldwide, cases of death and paralysis from polio have been reduced to less than 1,000 last year, from 350,000 worldwide in 1988.

But the campaign here has been deeply shaken by Taliban threats and intimidation, though several officials said Tuesday that they had never seen such a focused and deadly attack before.

Insurgents have long been suspicious of polio vaccinators, seeing them as potential spies. But that greatly intensified after the C.I.A. used a vaccination team headed by a local doctor, Shakil Afridi, to visit Osama bin Laden’s compound in Abbottabad, reportedly in an attempt to obtain DNA proof that the Bin Laden family was there before an American commando raid attacked it in May 2011.

In North Waziristan, one prominent warlord has banned polio vaccinations until the United States ceases drone strikes in the area.

Most new infections in Pakistan occur in the tribal belt and adjoining Khyber-Pakhtunkhwa Province — some of the most remote areas of the country, and also those with the strongest militant presence. People fleeing fighting in those areas have also spread the disease to Karachi, the country’s largest city, where the disease has been making a worrisome comeback in recent years.

After Tuesday’s attacks, witnesses described violence that was both disciplined and well coordinated. Five attacks occurred within an hour in different Karachi neighborhoods. In several cases, the killers traveled in pairs on motorcycle, opening fire on female health workers as they administered polio drops or moved between houses in crowded neighborhoods.

Of the five victims, three were teenagers, and some had been shot in the head, a senior government official said. Two male health workers were also wounded by gunfire; early reports incorrectly stated that one of them had died, the official said.

In Peshawar, the capital of Khyber-Pakhtunkhwa Province, gunmen opened fire on two sisters participating in the polio vaccination program, killing one of them. It was unclear whether that shooting was directly linked to the Karachi attacks.

In remote parts of the northwest, the Taliban threat is exacerbated by the government’s crumbling writ. In Bannu, on the edge of the tribal belt, one polio worker, Noor Khan, said he quit work on Tuesday once news of the attacks in Karachi and Peshawar filtered in. “We were told to stop immediately,” he said by phone.

Still, the Pakistani government has engaged considerable political and financial capital in fighting polio. President Asif Ali Zardari and his daughter Aseefa have been at the forefront of immunization drives. With the help of international donors, including the Bill and Melinda Gates Foundation, they have mounted a huge vaccination campaign aimed at up to 35 million children younger than 5, usually in three-day bursts that can involve 225,000 health workers.

The plan seeks to have every child in Pakistan immunized at least four times per year, although in the hardest-hit areas one child could be reached as many as 12 times in a year.

Declan Walsh reported from Islamabad, and Donald G. McNeil Jr. from New York. Salman Masood contributed reporting from Islamabad, and Zia ur-Rehman from Karachi, Pakistan.

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McDonald's urging franchisees to open on Christmas

McDonald's Corp. is urging U.S. restaurant owners to take the unusual step of opening on Christmas Day to deliver the world's biggest hamburger chain with the gift of higher December sales, AdvertisingAge reported Monday.

The request -- which comes as McDonald's tangles with resurgent rivals such as Wendy's, Burger King and Yum Brands' Taco Bell chain -- would be a break from company tradition of closing on major holidays.

"Starting with Thanksgiving, ensure your restaurants are open throughout the holidays," Jim Johannesen, chief operations officer for McDonald's USA, wrote in a Nov. 8 memo to franchisees -- one of two obtained by AdvertisingAge.

"Our largest holiday opportunity as a system is Christmas Day. Last year, (company-operated) restaurants that opened on Christmas averaged $5,500 in sales," Johannesen said.

"The decision to open our restaurants on Christmas is in the hands of our owner/operators," McDonald's spokeswoman Heather Oldani told Reuters.

Don Thompson took over as chief executive at McDonald's in July and has the difficult task of growing sales from last year's strong results in a significantly more competitive environment.

McDonald's monthly global sales at established restaurants fell for the first time in nine years in October, but unexpectedly rebounded in November.

The November surprise was partly due to a 2.5 percent rise in sales at U.S. restaurants open at least 13 months.

"Our November results were driven, in part, by our Thanksgiving Day performance," Johannesen wrote in a Dec. 12 memo to franchisees.

Oldani said 1,200 more McDonald's restaurants were open on Thanksgiving this year versus last year -- not 6,000 more as AdvertisingAge reported.

Still, the company has a high hurdle when it comes to posting an increase in restaurant sales this month because its U.S. same-restaurant sales jumped 9.8 percent in December 2011.

"It's an act of desperation. The franchisees are not happy," said Richard Adams, a former McDonald's franchisee who now advises the chain's owner/operators.

The push to open on the holidays goes against McDonald's cultural history, said Adams. In his first published operations manual, McDonald's Corp. founder Ray Kroc said the company would close on Thanksgiving and Christmas to give employees time with their families, Adams said.

"We opened for breakfast on Thanksgiving the last couple years I was a franchisee. It was easy to get kids to work on Thanksgiving because they want to get away from their family, but not on Christmas," Adams said.

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Merry Christmas, America-Haters?

When TNT was preparing its annual special “Christmas in Washington” with the president of the United States, you’d think the last star musician they would consider to join the official caroling would be Psy, the South Korean rapper. What on Earth is Christmasy about this man’s invisible-horse-riding dance to his dorky disco-rap hit “Gangnam Style”? It’s not exactly the natural flip-side to “O Holy Night.” But TNT couldn’t resist this year’s YouTube sensation.

This inane publicity stunt backfired when the website Mediaite reported on Dec. 7 that Psy (real name: Park Jae-sang) had participated in a 2002 protest in which he crushed a model of an American tank with a microphone stand. But that’s nothing compared to the footage of a 2004 performance after a Korean missionary was slaughtered by Islamists in Iraq. These lyrics cannot be misunderstood.

“Kill those f—-ing Yankees who have been torturing Iraqi captives … Kill those f—-ing Yankees who ordered them to torture … Kill their daughters, mothers, daughters-in-law and fathers … Kill them all slowly and painfully.”

This isn’t just anti-American. It’s anti-human.

Guess where this story first surfaced in the American media? CNN, from the same corporate family tree as TNT. It was posted back on Oct. 6 on CNN’s iReport, an open-source online news feature that allows users to submit stories for CNN consideration.

The Korean one-hit wonder put out the usual abject careerist apology, but he weirdly said, “I’m deeply sorry for how these lyrics could be interpreted.” Those darn lyrics and those darn people who misinterpret lyrics about killing Yankees’ mothers. It is like Barack Obama expressing regret for the awful things said about Susan Rice, ignoring the awful things said by Susan Rice.

Psy is now a millionaire. As Jim Treacher wrote at the Daily Caller: “So far he’s made over $ 8 million from the song, about $ 3 million of it from the people he once wanted to kill.” Brad Schaeffer at Big Hollywood noted his own father fought for South Korea’s independence in the Korean War: “Had it not been for ‘f——-g Yankees’ like my Dad, this now-wealthy South Korean wouldn’t be ‘Oppan Gangnam Style’ so much as ‘Starving Pyongyang Style.’” (Gangnam is a posh district in the South Korean capital of Seoul.)

Despite the controversy, neither the Obama White House nor the TNT brass felt it was necessary to send Psy packing before the Dec. 9 taping. On Saturday, ABC reporter Muhammad Lila merely repeated, “the White House says the concert will go on and that President Obama will attend, saying that they have no control over who performs at that concert.”

What moral cowardice. On Monday morning, another pliant publicist, NBC correspondent Peter Alexander, calmly relayed that the White House did take control on the Psy front — on its own “We The People” website, where the people may post petitions to the president for their fellow citizens to sign. A petition asking Obama to dump Psy from the Christmas concert was itself dumped. Alexander explained: “But that petition was removed because the rules say the petitions only apply to federal actions. And, of course, the President had no say over who the private charity chose to invite.”

This is double baloney. The White House hasn’t removed silly “federal action” petitions like the one asking to “Nationalize the Twinkie Industry,” or one to “Secure resources and funding, and begin construction of a Death Star by 2016.” They removed one that they didn’t want people to sign.

As for Obama having “no say over” who appeared on the TNT show, the president could easily declare he wasn’t going to share a stage with this America-hater. Or he could have obviously placed one phone call to Time Warner CEO Jeff Bewkes (an Obama donor), and expressed the dismay of the President of the United States.

Instead, the Obamas came and honored Psy. Yes, the president honored a man who despised America enough to want its citizens slaughtered.

John Eggerton of Broadcasting and Cable magazine observed, “At the end of the taping, when the First Family customarily shakes hands and talks briefly with the performers, the First Lady gave Psy a hug, followed by a handshake from the President, who engaged Psy in a short, animated discussion — at one point Psy appeared to rock back with laughter — and patted the singer on the shoulder.”

I never thought I’d ever view a Christmas special featuring a hideous hater of America celebrated by the President of the United States.

L. Brent Bozell III is the president of the Media Research Center. To find out more about Brent Bozell III, and read features by other Creators Syndicate writers and cartoonists, visit the Creators Syndicate Web page at www.creators.com.

COPYRIGHT 2012 CREATORS.COM

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Some good, some bad reviews for CTA's 'de-crowding' plan

CTA commuters respond to the first day of a "de-crowding" plan, where 12 bus routes were cut and trains added to service the morning rush hour.

The CTA attempted to de-crowd buses and trains Monday — and da crowd cheered and da crowd booed.

Old habits, particularly commuting habits, are highly resistant to change. That was the case for many transit customers forced to try a new way to work and home because their usual bus routes were eliminated or truncated to save the CTA $16 million that the agency invested in expanded service on other bus routes and rail lines.

"I'm devastated, (and) I'm probably going to move," Katie Blochowiak, a teaching assistant with Chicago Public Schools, said while waiting to board a Brown Line train at the Western station.

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The CTA's move to eliminate the section of the No. 11 Lincoln/Sedgwick bus route between Western and Fullerton upended Blochowiak's commute between her home in the Lincoln Square neighborhood and her school in the Lakeview neighborhood, she complained, because now she must walk much farther.

John Hyland said it would be nice to have the No. 11 as an option, but he'd rather ride the Brown Line. The "rapid" was put back into rapid transit during his morning commute.

"Sometimes I'll wait for two or three trains" on the Brown Line before being able to get on comfortably because of overcrowding, said Hyland, who boarded the first train that came by his stop Monday morning at Sedgwick.

The train had plenty of room for standing passengers.

"Today, no issue. Just walked right on," Hyland said. "Little more elbow room."

Red Line rider Candi Stromwell, 31, would agree. "This is the way my commute should be every day," Stromwell said as she found an open seat on the train at Fullerton.

But Glenn Eckstein, a software developer who rode the Brown Line train behind Hyland's, said he didn't notice any improvement. "Exactly the same," he grumbled after getting off a packed train at the Merchandise Mart.

The easing of congestion — resulting from extra service and adjustments to waiting times on 48 bus routes and six rail lines — might also have gotten a boost from what appeared to be a generally lighter morning rush just a week before Christmas.

In addition, Monday was the first day of the winter schedule for CTA bus and rail operators — with "slightly new timetables, a minute or two here and there," CTA spokesman Brian Steele said.

The full effect of the changes on ridership won't be seen until after the first of the year, when commuters return to work after the holidays, Steele said.

Overall, the first day of changes went "fairly smoothly" in the CTA's view, Steele said. Ridership data from Monday won't be available until later this week, he said, so no comparisons could be immediately made to a previous Monday.

"Anecdotally, we did see, and hear about via social media, improved conditions on a number of bus and rail routes," he said.

CTA staffers are taking note of the general capacities of trains and buses and looking for areas where service tweaks might be considered, Steele said.

Unlike passengers — who, given a choice, would always avoid congested highways, airports and transit vehicles — transportation providers thrive on congestion. The airline hub-and-spoke system is based on scheduling large numbers of planes into a major airport from various smaller airports in a short span of time, then transferring passengers from one aircraft to another so they can reach their final destinations. Airlines are willing to accept the delays that inevitably result as simply a cost of doing business.

Transit agencies are attracted to congestion, too, because passengers jammed into trains and buses mean more fare revenue to help pay operating costs. It's why the CTA often runs four-car trains packed with passengers in the middle of the day on the Green and Brown lines even though riders would be much more comfortable in a six-car train.

Random counts of riders per train car conducted by a Tribune reporter Monday morning indicated 65 to 75 passengers on many of the cars on the Red, Brown and Purple lines. The new targeted maximum under the CTA's crowding-reduction plan is 70 to 75 passengers per car, which is down from 90 or more passengers per car during the height of rush periods when trains are packed at "crush loads," officials said.

The new maximum occupancy goal on a regular 40-foot bus is 45 to 55 passengers instead of 70, officials said.

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Amazon adds episodes of alt-comedy show “UnCabaret”

LOS ANGELES (TheWrap.com) – Amazon Instant Video has added four exclusive episodes of “UnCabaret,” an alt-comedy showcase for the likes of Margaret Cho and Andy Dick, to its Prime Instant Video service.

The show was created and hosted by comedian and entertainer Beth Lapides and features performances by such comedy stars as Sandra Bernhard, Garfunkle and Oates, Greg Fitzsimmons and Rob Delaney. Instead of punch-line driven sets, performers are encouraged to show off story-based stream-of-consciousness acts.

Amazon Prime members will get free access to the titles. The episodes will be available for rental or purchase for Amazon Instant Video customers on an a la carte basis.

Amazon Prime costs $ 79 annually and gives members free two-day shipping as well as streaming access to movies and shows from the likes of Paramount and Disney-ABC. The catalog of titles grew a little larger Monday. In addition to “UnCabaret,” Amazon announced an exclusive content licensing agreement with Turner Broadcasting System and Warner Bros. TV to add two TNT shows, “Falling Skies” and “The Closer” to its service.

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N.I.H. to Start Initiatives to Raise Number of Minority Scientists

Few blacks enter biomedical research, and those who do often encounter obstacles in their career paths.

A study published last year found that a black scientist was markedly less likely to obtain research money from the National Institutes of Health than a white one — even when differences of education and stature were taken into account.

The institute has now announced initiatives aimed at helping blacks and other ethnic and racial groups who have been unrepresented among medical researchers, including a pilot program that will test a grant review process in which all identifying information about the applicant is removed.

The initiatives take a step further than addressing the problem identified in the study — the goal is to entice more minorities into the field.

“It needed to go well beyond that,” said Francis S. Collins, director of the N.I.H., “because even if we fixed that, it would still be the case that there would be a very distressingly low number of individuals from underrepresented groups who are part of what we’re trying to do in science.”

The N.I.H. program will provide research opportunities for undergraduate students, financial support for undergraduate and graduate students, and set up a mentoring program to help students and researchers beginning their careers.

When the program ramps up, it will cost about $50 million a year and support about 600 students.

The N.I.H. formed a group of 16 scientists to study the causes of the problem, and the group presented its recommendations in June. At a meeting this month of his advisory committee, Dr. Collins and other officials discussed how to implement the recommendations.

At the meeting, Dr. Reed Tuckson, an executive vice president and the chief of medical affairs for UnitedHealth Group, who was one of the group’s co-chairman, acknowledged the controversies that would inevitably accompany the effort, especially as the N.I.H., like the rest of the federal government, could soon face sizable cuts in its budget.

“This is a heavy, laden issue which no matter which way you turn, someone is going to be irritated,” he said.

Dr. Tuckson, who is black, urged his colleagues to support the efforts. “A lot of people put themselves on the line,” he said.

The study last year, published in the journal Science, reviewed 83,000 grant applications between 2000 and 2006. For every 100 applications submitted by white scientists, 29 were awarded grants. For every 100 applications from black scientists, only 16 were financed.

After statistical adjustments to ensure a more apples-to-apples comparison, the gap narrowed but persisted.

That raised the uncomfortable possibility that the scientists reviewing the applications were discriminating against black scientists, possibly reflecting an unconscious bias. Members of other races and ethnic groups, including Hispanics, do not appear to run into the same difficulties, the study said.

Only about 500 doctoral degrees in a year in biological sciences go to underrepresented minorities, like blacks, Hispanics and Native Americans.

To persuade more students to pursue this as a career, the N.I.H. aims to provide more summer research opportunities for undergraduates.

“That is the single strongest predictor of somebody deciding that that’s the career they want to pursue,” Dr. Collins said of mentored research.”

The program will also provide money to professors so that they can have more time to mentor students or train new mentors.

“They’re talking about a multipronged approach, which I think is a smart approach,” said Dr. Raynard S. Kington, president of Grinnell College in Iowa and a former deputy director of N.I.H. who was a co-author of the Science paper. “If they had just said, ‘We’re going to focus on review,’ I would have been deeply disappointed.”

Donna K. Ginther, an economics professor at the University of Kansas who led the Science study, has taken a closer look at a subset of 2,400 proposals included in the original study. It turns out, she said, that the black applicants published fewer papers and have fewer co-authors than other scientists.

That helps explain the financing gap, but also suggests that the professional networks of black scientists are smaller. “The hypothesis being that professionally, they’re not as integrated,” Dr. Ginther said, “and that’s why I think the mentoring network is such a good idea.”

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